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Carolyn S. Calfee, MD MAS is Professor of Medicine and Anesthesia at the University of California, San Francisco, where she attends in the intensive care units. Her primary academic focus is the pathogenesis and treatment of the acute respiratory distress syndrome (ARDS). Current research projects include: (1) molecular subphenotypes of ARDS and precision medicine in critical care; (2) the role of environmental exposures including smoking, air pollution, and novel tobacco products in susceptibility to lung injury; and (3) novel treatments for ARDS. During the COVID-19 pandemic, she has been the UCSF clinical lead and steering committee member for the NIAID-funded Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study and she is one of the lead PI’s for the ISPY COVID clinical trial, a Phase 2 adaptive platform clinical trial of novel treatments for COVID-19 associated ARDS.